徐建雄 职    称：长聘教授 所属学科： 动物营养与饲料科学  研究方向：（1）分子营养                  （2）氧化应激与动物健康                  （3）生态养殖 电话/传真：021-34205767 电子信箱：jxxu1962@sjtu.edu.cn 联系地址：必威A楼3-307室

 

个人简介：

徐建雄，博士，教授，博士生导师。兼任中国畜牧兽医学会动物营养学分会理事，NIH访问学者，上海市曙光学者。

近年来，主要从事动物肠道发育与营养调控、氧化应激与动物健康、生态养殖模式研究以及新型饲料添加剂研发。先后完成国家自然科学基金、国家重点研发计划项目、公益性行业（农业）科研专项、以及省部级科研项目30余项，在国内外学术刊物发表论文120余篇，获省部级科技进步奖二等奖3项和三等奖6项，上海市优秀发明一等奖1项，获国家发明专利14项，转让9项。

主要成果：     

近期代表性论文：

1. Zhen Luo , Qingying Gao , Hongcai Zhang , Yitian Zhang , Shujie Zhou , Jing Zhang , Weina Xu , Jianxiong Xu* Microbe-derived antioxidants attenuate cobalt chloride-induced mitochondrial function, autophagy and BNIP3-dependent mitophagy pathways in BRL3A cells Ecotoxicology and Environmental Safety 232 (2022) 113219

2. Ma, S.; Zhang, H.; Xu, J.* Characterization, Antioxidant and Anti-Inflammation Capacities of Fermented Flammulina velutipes Polyphenols. Molecules 2021, 26,6205. https://doi.org/10.3390/molecules26206205

3. Hongcai Zhang, Tingting Qiu, Yifei Bai , Bin Chen, Juan Yan, Jianxiong Xu* Enhanced antibacterial activity of lysozyme loaded quaternary ammonium chitosan nanoparticles functionalized with cellulose nanocrystals International Journal of Biological Macromolecules 191 (2021) 71-78

4. Zhen Luo , Jianbo Yao , Jianxiong Xu* Reactive oxygen and nitrogen species regulate porcine embryo development during pre-implantation period: A mini-review Animal Nutrition 7 (2021) 823e828

5. Luo,W.; Li, L.; Xu,W.;Zhang, J.; Xu, J.* Toxic Effects of Docosahexaenoic Acid Treatment in the Rat Liver BRL-3A Cell. Toxics 2021, 9, 112. https://doi.org/10.3390/toxics9050112

6. Luo,W.; Yin, X.; Yao, ;Cheng, J.; Zhang, J.; Xu,W.; Mu, Y.;Xu, J.* Fermented Soybean Meal Affects the Reproductive Performance and Oxidative Status of Sows, and the Growth of Piglets. Animals 2021, 11,597. https://doi.org/10.3390/ani11030597

7. Wenli Luo , Weina Xu , Jing Zhang , Jianbo Yao  and Jianxiong Xu* The Maternal Diet with Fish Oil Might Decrease the Oxidative Stress and Inflammatory Response in Sows, but Increase the Susceptibility to Inflammatory Stimulation in their of Offspring. Animals 2020, 10, 1455; doi:10.3390/ani10091455

8. Hao Zhang, Yanan Chen, Yueping Chen, Peilu Jia, Shuli Ji, Jianxiong Xu*, Yue Li and Tian Wang Comparison of the effects of resveratrol and its derivative pterostilbene on hepatic oxidative stress and mitochondrial dysfunction in piglets challenged with diquat† Food Funct., 2020, 11, 4202–4215

9. Zhen Luo, Xue Xu, Takami Sho, Jing Zhang, Weina Xu, Jianbo Yao, and Jianxiong Xu* ROS-induced autophagy regulates porcine trophectoderm cell apoptosis,proliferation, and differentiation. Am J Physiol Cell Physiol 2019 316:C198-C209

10. Zhen Luo, Xue Xu, Takami Sho, Wenli Luo, Jing Zhang, Weina Xu, Jianbo Yao, and Jianxiong Xu* Effects of n-acetyl-cysteine supplementation in late gestational diet on maternal-placental redox status, placental NLRP3 inflammasome, and fecal microbiota in sows. J.Anim.Sci.2019.97:1757–1771 doi:10.1093/jas/skz058

11. W. L. Luo , Z. Luo,X. Xu,S. Zhao,S. H. Li,T. Sho,J. Yao,J. Zhang,W. N. Xu,and J. X. Xu* The Effect of Maternal Diet with Fish Oil on Oxidative Stress and Inflammatory Response in Sow and New-Born Piglets Oxidative Medicine and Cellular Longevity 2019, Article ID 6765803, https://doi.org/10.1155/2019/6765803

12. Zhen Luo, Xue Xu, Sen Zhao, Takami Sho, Wenli Luo, Jing Zhang, Weina Xu, Kong Hon and Jianxiong Xu* Inclusion of microbe-derived antioxidant during pregnancy and lactation attenuates high-fat diet-induced hepatic oxidative stress, lipid disorders, and NLRP3 inflammasome in mother rats and offspring. Food & Nutrition Research 2019, 63: 3504 - http://dx.doi.org/10.29219/fnr.v63.3504

13. Takami Sho, JianXiong Xu* Role and mechanism of ROS scavengers in alleviating NLRP3‐mediated inflammation. Biotechnology and Applied Biochemistry.2018 66,(1):4–13

14. Zhen Luo, Wenli Luo, Shaohua Li, Sen Zhao, Takami Sho, Xue Xu, Jing Zhang, Weina Xu,Jianxiong Xu* Reactive oxygen species mediated placental oxidative stress, mitochondrial content, and cell cycle progression through mitogen-activated protein kinases in intrauterine growth restricted pigs. Reproductive Biology 18 (2018) 422–431

15. Xuan Cai, Lihui Zhu, Xiaolian Chen,Yongshuai Sheng, Qi Guo, Jian Bao &Jianxiong Xu* X. XO or H2O2 induced IPEC-J2 cell as a new in vitro model for studying apoptosis in post-weaning piglets. Cytotechnology .2016. 68:713–724

16. Zhen Luo, Wei Zhu, Qi Guo,Wenli Luo, Jing Zhang, Weina Xu, and Jianxiong Xu* Weaning Induced Hepatic Oxidative Stress, Apoptosis, and Aminotransferases through MAPK Signaling Pathways in Piglets. Oxidative Med Cell Longev, 2016, Article ID 4768541, 10 pages

17. Jianxiong Xu, Congcong, Xiaolian Chen, Xuan Cai,Shoufeng Yang, Yongshuai Sheng, Tian Wang. Regulation of an antioxidant blend on intestinal redox status and major microbiota in early weaned piglets. Nutrition. 2014.30:584–589

18. C. C. Xu, S. F. Yang, L. H. Zhu, X. Cai, Y. S. Sheng, S. W. Zhu and J. X. Xu* Regulation of N-acetyl cysteine on gut redox status and major microbiota in weaned piglets. J. Anim. Sci. 2014.92:1504-1511

19. L. H. Zhu, J. X. Xu*, S. W. Zhu, X. Cai, S. F. Yang, X. L. Chen and Q. Guo. Gene expression profiling analysis reveals weaning-induced cell cycle arrest and apoptosis in the small intestine of pigs. J. Anim. Sci. 2014.92 :996-1006

20. Lihui Zhu, Xuan Cai1, Qi Guo, Xiaolian Chen, Suwen Zhu and Jianxiong Xu* Effectof N-acetylcysteine on enterocyte apoptosis and intracellular signalling pathways response to oxidative stress in weaned piglet. British Journal of Nutrition, 2013.110, 1938–1947

21. L. H. Zhu, K. L. Zhao, X. L. Chen and J. X. Xu* Impact of weaning and an antioxidant blend on intestinal barrier function and antioxidant status in pigs. J. Anim. Sci.2012.90:2581–2589

22. X. L. Chen, L. Z. Gong and J. X. Xu* Preventive effect of probiotics on sperm damage induced by diet Oxidative stress in rats. Animal, 2012.1 of 6

 

代表性授权发明专利：

1. 一种小肽微量元素螯合物螯合率的检测方法. ZL201810811488.4

2. 用于促进繁殖母羊氧化还原平衡的饲料添加剂及其应用ZL 201611235000.5

3. 猪用营养性抗应激生物修复组合物及其制备方法 ZL20120553201.5

4. 提高雄性动物精液品质的复合抗氧化剂 ZL 201010515368.3

5. 抗氧化保健鸡蛋的生产方法及其使用的复合抗氧化剂 ZL 201110247562.2

6. 复合益生菌发酵饲料的制备方法 ZL 201010129568.5

7. 猪双低菜籽粕复合饲料添加剂 ZL200410089291.2

8. 纳米沸石组装体固载植酸酶复合饲料添加剂的制备方法 ZL 201310304269.4

9. 抗仔猪细菌性疫病复合卵黄抗体制剂的制备方法ZL200410084559.3

10. 卵黄抗体饲料添加剂的制备方法 ZL 200710040002.3