职    称：教授 所属学科：植物科学 研究方向： 1）植物（真菌）生物技术；2）药用植物（真菌）资源及功能基因的开发利用。 电话/传真：021-34205778 电子信箱：xuanweizhou@sjtu.edu.cn 联系地址：上海市东川路800号，上海交大必威B311

 

个人简介：

周选围，男，1962年生，博士，陕西咸阳人。必威教授/博士生导师。1984毕业于现陕西理工大学并参加工作，分别在汉中师范学院、陕西理工学院、陕西理工大学工作至2004年，历任助教、讲师、副教授、教授。工作期间在华东师范大学学习硕士学位课程，在上海师范大学学习获得博士学位。2004年11月至今在必威植物科学系工作，2011.5~2012.5在美国马里兰大学（University of Maryland College Park, MD）访问学者。曾任陕西省食品学会理事、汉中市食品与生物工程学会秘书长，现为中国菌物学会、上海市生物工程学会等会员。担任《Journal of Plant Science and Pathology》主编、《Chinese Traditional Medicine Journal》编委。

 

主要成果：

主编《生物技术概论》（高等教育出版社，2010）获上海交通大学优秀教材二等奖，并入选“十二五”普通高等教育本科国家级规划教材”（2014），2019以新形态教材形式再版；“生物技术教育课程建设与应用”获得上海交通大学2015年度教学成果奖、校长教学奖二等奖；2019年获得上海交通大学“教书育人奖”个人奖（提名奖）。主讲《生物技术概论》、《生物技术与人类》等课程；《生物技术概论》作为大规模在线开放课程（MOOC）在“爱课程”网“中国大学MOOC”平台上线运行。

曾主持或参加国家重点研发计划、国家高技术研究发展计划（863计划）重点项目、国家自然基金面上项目、上海市科委、企事业单位委托项目等各级各类科研项目10余项。运用DNA改组技术对FIPs 基因改组，为其体外生产合成和改善蛋白的生物学活性奠定基础；初步揭示了该家族蛋白的抗肿瘤作用及其作用机制。在Journal of Agriculture and Food Chemistry、Applied Microbiology and Biotechnology、Journal of Cellular Physiology、Food and Agricultural Immunology、Critical Reviews in Biotechnology、Drug discovery Today、中国科学、应用环境与生物学报等国内外专业期刊上发表各类学术论文100余篇，其中SCI收录50余篇；获得国家授权发明专利10项。

 

近期代表性论文：（第一或通讯）

[1] Li QZ, Zheng YZ, and Zhou XW*. Fungal immunomodulatory proteins: characteristic, potential anti-tumor activities and their molecular mechanisms. Drug Discovery Today, 2019, 24(1): 307-314.

[2] Xia F, Zhou X, Liu Y, Li YL, Bai XH, & Zhou XW*. Composition and predictive functional analysis of bacterial communities inhabiting Chinese Cordyceps insight into conserved core microbiome. BMC Microbiology, 2019, 19(1), 105. 

[3] Li QZ, Chang YZ, He ZM, Chen L, Zhou XW*. Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling athways in RAW264.7 cells. Journal of Cellular Physiology. 2019, 234:23337–23348. 

[4] Zheng YZ, Li QZ, Shao KD, Mao PW, Liu Y, Zhou XW*. Expression of Ganoderma lucidum fungal immunomodulatory protein (FIP-glu) in Saccharomyces cerevisiae and its Immunoreactivity. International Journal of Agriculture and Biology. 2019,22(2): 369-374.

[5] Shao KD, Mao PW, Li QZ, Li LDJ, Wang YL, Zhou XW*. Characterization of a novel fungal immunomodulatory protein, FIP-SJ75 shuffled from Ganoderma lucidum, Flammulina velutipes and Volvariella volvacea. Food and Agricultural Immunology. 2019, 30(1): 1253–1270. 

[6] Liu Y, Mao PW, Jin MY, Bai XH, Zhou XW*. Breaking the sporoderm of Ganoderma lucidum spores by combining enzymatic hydrolysis reaction with physical actuation. Biocell. 2019, 43(7-1): 458-465.

[7] Li LDJ, Mao PW, Shao KD, Bai XH, Zhou XW*. Ganoderma proteins and their potential applications in cosmetics. Applied Microbiology and Biotechnology. 2019, 103:9239–9250

[8] Li QZ, Chang YZ, Su KQ, Wang XL, Bai XH, Zhou XW*. Cloning and characterization of the promoters of fungal immunomodulatory proteins gene from Ganoderma spp. and their response to methyl jasmonate and salicylic acid. International Journal of Medicinal Mushrooms. 2018, 20(2): 177-189.

[9] Xu H, Guo MY, Gao YH, Bai XH，Zhou XW*. Expression and characteristics of manganese peroxidase from Ganoderma lucidum in Pichia pastoris and its application in the degradation of four dyes and phenol. BMC Biotechnology. 2017, 17:19.

[10] Guo MY, Liu Y, Gao YH, Jin T, Zhang HB, Zhou XW*.  Identification and Bioactive Potential of Endogenetic Fungi Isolated from Medicinal Caterpillar Fungus Ophiocordyceps sinensis from Tibetan Plateau. International Journal of Agriculture & Biology. 2017, 19(2):307-313.

[11] Xia F, Chen X, Guo MY, Bai XH, Liu Y, Shen GR, Li YL, Lin J, Zhou XW*. High-throughput sequencing-based analysis of endogenetic fungal communities inhabiting the Chinese Cordyceps reveals unexpectedly high fungal diversity. Scientific Reports. 2016, 6:33437.

[12] Xu H, Kong YY, Chen X, Guo MY, Bai XH, Lu YJ, Li W，Zhou XW*. Recombinant FIP-gat, a fungal immunomodulatory protein from Ganoderma atrum, induces growth inhibition and cell death in breast cancer cells. Journal of Agricultural and Food Chemistry. 2016, 64(13):2690-2698.

[13] Xia F, Liu Y, Guo MY, Shen GR, Lin J, Zhou XW*. Pyrosequencing analysis revealed complex endogenetic microorganism community from natural DongChong XiaCao and its microhabitat. BMC Microbiology. 2016, 6(1):196.

[14] Zhou XW*, Liu Yan, Su KQ, Zhang YM. Species clarification of the widely cultivated Ganoderma in China based on rDNA and FIP gene sequence analysis. International Journal of Agriculture & Biology. 2016, 18(5):932- 938. 

[15] Xia F, Liu Y, Shen GR, Lin J, Zhou XW^*. Investigation and analysis of microbiological communities in natural Ophiocordyceps sinensis. Canadian Journal of Microbiology. 2015, 61(2): 104-111 

[16] Zhou XW^*, Su KQ, Zhang YM. Phylogenetic analysis of widely cultivated Ganoderma in China based on the mitochondrial V4-V6 region of SSU rDNA. Genetics and Molecular Research. 2015,14(1): 886-897.

[17] Zhou XW*, Li LJ, Tian EW. Advances in research of artificial cultivation of Ophiocordyceps sinensis in China. Critical Review in Biotechnology. 2014, 34(3): 233-43.

[18] Cong WR, Xu H, Liu Y, Li QZ, Li W, Zhou XW*. Production and functional characterization of a novel fungal immunomodulatory protein FIP-SN shuffled from two genes of Ganoderma species. Applied Microbiology and Biotechnology. 2014, 98(13):5967-75.

[19] Cong WR, Liu Y, Li QZ, Zhou XW*. Cloning and analysis of a functional promoter of fungal immunomodulatory protein from Flammulina velutipes. Molecular Biology Reports. 2014, 41(7):4381-7.

[20] Cong WR, Gong ZH, Shi DD, Zhou XW*. Cloning and analysis of mating-type gene MAT1-1-1 from Cordyceps militaris. International Journal of Medicinal Mushrooms. 2014, 16(5) : 449-462.

[21] Liu Y, Yuan WN, Zhou XW^*. Optimization of submerged culture conditions for the mycelial biomass and bioactive metabolites production by Cordyceps militaris. Journal of Pure and Applied Microbiololgy. 2014, 8(6): 4245-4254.

[22] Wang XF, Li QZ, Bao TW, Cong WR, Zhou XW*. In vitro rapid evolution of fungal immunomodulatory proteins by DNA family shuffling. Applied Microbiology and Biotechnology. 2013, 97(6): 2455-2465.

[23] Zhou XW*, Cong WR, Su KQ, Zhang YM. Ligninolytic enzymes from Ganoderma spp.-Current status and potential applications. Critical Review in Microbiology. 2013, 39(4):416-26

[24]  Zhou XW*, Su KQ, Zhang YM. Applied modern biotechnology for cultivation of Ganoderma and development of their products. Applied Microbiology and Biotechnology. 2012, 93(3):941-963.

[25] Zhou XW*, Wang XF, Li QZ. Expression and characteristic of the Cu/Zn superoxide dismutase gene from the insect parasitizing fungus Cordyceps militaris. Molecular Biology Reports. 2012, 39(12):10303-10311.

[26] Wang XF, Su KQ, Bao TW, Cong WR, Chen YF, Li QZ, Zhou XW*. Immunomodulatory effects of fungal proteins. Current Topics in Nutraceutical Research. 2012,10 (1): 1-11.

[27] Li QZ, Huang L, Wang XF, Li XS, Wu SQ, Zhou XW*. Fungal immunomodulatory protein from Flammulina velutipes induces cytokine gene xpression in mouse spleen cells. Current Topics in Nutraceutical Research. 2011, 9(3): 111-118.

[28] Li QZ, Wang XF, Zhou XW*. Recent status and prospects of the fungal immunomodulatory protein family. Critical Reviews in Biotechnology. 2011, 31(4): 365-375.

[29] Li QZ, Zheng SB, Wang XF, Bao TW, Zhou XW*. Preparation of rabbit anti-Ganoderma sinensis immunomodulatory protein polyclonal antibody. African Journal of Microbiology Research. 2011, 5(12): 1562-1564.

[30] Li QZ, Wang XF, Bao TW, Ran L, Lin J, Zhou XW*. In vitro synthesis of a recombinant fungal immunomodulatory protein from Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W.Curt.:Fr.) P.Karst. (Aphyllophoromycetideae) and analysis of its immunomodulatory activity. International Journal of Medicinal Mushrooms, 2010, 12(4):347–358.

[31] Li QZ, Wang XF, Chen YY, Lin J, Zhou XW*. Cytokines expression induced by Ganoderma sinensis fungal immunomodulatory proteins (FIP-gsi) in mouse spleen cells. Applied Biochemistry and Biotechnology. 2010, 162(5):1403-1413.

[32] Zhou XW*, Zhu HF, Liu L, Lin J. Recent advances and prospect on taxol-producing endophytic fungi. Applied Microbiology and Biotechnology. 2010, 86(6): 1707-1717.

[33] Zhou XW*, Xie MQ, Hong F, Li QZ, Lin J. Genomic clones and characterization of a FIP-gsi gene encoding a fungal immunomodulatory protein from Ganoderma sinensis. International Journal of Medicinal Mushrooms. 2009, 11(1):77-86.

[34] Zhou XW*, Zheng WL, Zhu HF, Tang KX. Identification of a taxol-producing endophytic fungus EFY-36. African Journal of Biotechnology. 2009, 2009, 8(11): 2623-2625.

[35] Gong ZH, Su Y, Huang L, Lin J, Tang KX, Zhou XW*. Cloning and analysis of glyceraldehyde-3- phosphate dehydrogenase gene from Cordyceps militaris. African Journal of Agricultural Research. 2009, 4(4): 402-408.

[36] Huang L, Li QZ, Chen YY, Wang XF, Zhou XW*. Determination and analysis of cordycepin and adenosine in the products of Cordyceps spp. African Journal of Microbiology Research. 2009, 3(12): 957-961.

[37] Zhou XW, Gong ZH, Su Y, Lin J, Tang KX. Cordyceps fungi: natural products, pharmacological functions and developmental products. Journal of Pharmacy and Pharmacology. 2009, 61(3):279-291.

[38] Zhou XW, Li QZ, Yin YZ, Chen YY, Lin J. Identification of medicinal Ganoderma species based on PCR with specific primers and PCR-RFLP. Planta Medica. 2008, 74(2): 197-200.

[39] Zhou XW, Wei YM, Zhu HF, Wang ZN, Lin J, Liu L, Tang KX. Protoplast formation, regeneration and transformation from the taxol-producing fungus Ozonium sp. African Journal of Biotechnology. 2008, 7 (12): 2017-2024.

[40] Zhou XW, Lin J, Yin YZ, Zhao JY, Sun XF, Tang KX. Ganodermataceae: natural products and their related pharmacological functions. American Journal of Chinese Medicine. 2007, 35(4): 559-574.

[41] Zhou XW, Lin J, Yin YZ, Sun XF, Tang KX. Participation in Research Program: a novel course in undergraduate education of life science. Biochemistry and Molecular Biology Education. 2007, 35(5):322-327

[42] Zhou XW, Lin J, Yin YZ, Li QZ, Zhao JY, Tang KX. Comparison of rapid DNA extraction methods applied to PCR identification of medicinal mushroom Ganoderma spp. Preparative Biochemistry & Biotechnology. 2007, 37(4): 369- 380.

[43] Zhou XW, Jiang H, Lin J, Tang KX. Cytotoxic activities of Coriolus versicolor (Yunzhi) extracts on human liver cancer and breast cancer cell line. African Journal of Biotechnology. 2007, 6(15):1740-1743.

[44] Zhou XW, Wang ZN, Jiang KJ, Wei YM, Lin J, Sun XF, Tang KX. Screening of taxol-producing endophytic fungi from Taxus chinensis var. mairei. Applied Biochemistry and Microbiology. 2007, 43(4):439-443.

[45] Zhou XW, Lin J, Zhang L, Chen ZH, Yin YZ, Guo BH, Sun XF and Tang KX. The development of biotechnology education in China. Biochemistry and Molecular Biology Education. 2006, 34(2): 141-147.

[46]高秀莲,毛培文,黎刘定吉,周选围*.不同粒色青稞及其生物处理样品中脂肪含量和脂肪酸组成分析.上海交通大学学报(农业科学版).2019,37(6): 50-56.

[47]刘玲，李奇璋，周选围*，王玉亮. 重组黑芝免疫调节蛋白对小鼠巨噬细胞RAW264.7向M1型分化的影响. 食品科学. 2019,40 (23):170~175.

[48]刘栋，王萍，周智伟，周选围*. 红曲霉发酵青稞中添加辅料对γ-氨基丁酸含量的影响.粮油食品科技. 2018,26(1): 95-100.

[49]张四维, 岑凯, 刘艳, 周选围*，王成树. 青藏高原野生冬虫夏草子实体发育时期的宏转录组研究. 中国科学:生命科学, 2018, 48: 1–9.

[50]高艳华, 李奇璋, 刘玲, 郑雨璋, 周选围*. 重组真菌免疫调节蛋白对巨噬细胞RAW 264.7激活应答的研究. 上海交通大学学报（农业科学版），2018，36, 53-58, 65.

[51]沈娜，黄楠楠，周选围*. 发芽青稞面包加工工艺优化.粮油食品科技. 2017, 25(1):11-14.

[52]郭梦圆, 高艳华, 郑雨璋, 王萍, 夏 飞, 周选围*. 冬虫夏草内生菌NS2-B1发酵培养基的筛选.应用生物与环境学报. 2017,23 ( 5 ): 0939-0944

[53]徐慧, 郭梦圆, 靳通, 高艳华, 路慧丽, 李伟，周选围*. 灵芝锰过氧化物酶毕赤酵母工程菌培养条件的优化. 第二军医大学学报. 2016,37(8):955-962.

[54]许燕, 胡明慧, 高蓓蓉, 周选围*. 灵芝真菌免疫调节蛋白在体外对不同胃癌细胞的抑制作用. 药学实践杂志, 2016, 34(3): 223-226.

[55]张伊迪,周选围*.青稞籽粒中β-葡聚糖在发芽过程中的变化.中国农学通报. 2014, 30(24): 294-298.

[56]苏恺琪, 王雪飞, 周选围. 黑灵芝免疫调节蛋白基因的克隆和生物信息学分析. 上海交通大学学报（农业科学版）. 2012, 30(1): 65-71.

[57]郑文龙，朱慧芳，刘璐，叶巍，周选围*,尹京苑.产紫杉醇内生真菌EFY- 21 的鉴定与生物学特性研究.菌物研究. 2010, 8(1): 35-40.

[58]朱慧芳，郑文龙，王玉亮，冯小路，周选围*. 三种红豆杉属植物中紫杉烷类化合物含量的检测与分析. 上海交通大学学报（农学版）, 2010, 28(1): 9-13.

[59]李奇璋, 王雪飞, 黄蕾, 周选围*. 紫芝免疫调节蛋白基因的原核表达与功能分析. 西北植物学报, 2010 ,30 (1) :0035-0040.

[60]苏颖,周选围*.改进苯酚-硫酸法快速测定虫草多糖含量. 食品研究与开发. 2008, 29(3):118-211.

[61]黄蕾,许滨竑,苏颖,龚振华,王玉亮,周选围*. 虫草属真菌中主要活性成分含量的比较. 上海交通大学学报（农学版）. 2008,26(1): 74-77.

[62]苏颖, 宋艳, 黄蕾, 邹豪, 周选围* 复方虫草多糖含片质量控制方法的研究,药学实践杂志. 2008, 26(3):191-193,221.

[63]周选围, 林娟, 李奇璋, 尹燡周, 孙小芬, 唐克轩. 灵芝蛋白类活性成分的研究进展. 天然产物开发与研究. 2007, 19(5):917-924.

[64]周选围, 林娟, 孙小芬, 唐克轩. 中药指纹图谱与灵芝质量标准研究方法.中草药2006,37(8): 1121-1125.

[65]周选围,王子楠,魏雅敏,林娟,孙小芬,谈峰, 苗志奇,唐克轩. 红豆杉内生真菌发酵培养基和原生质体制备酶系统的筛选.应用与环境生物学报.2006,12 (2):176-181. 

[66]周选围, 陈文强,邓百万,王智,彭浩,林娟. 生物技术在药用真菌资源开发与保护中的应用.中草药. 2005, 36(3):451-455.

 

代表性授权发明专利：

[1]周选围，孔应予，丛蔚然. 黑灵芝真菌免疫调节蛋白的制备方法及其应用。专利号：201410009107.2. （授权日：2016-08-30）

[2]周选围，丛蔚然. 一种属内重组真菌免疫调节蛋白的制备方法及其应用. 专利号：201310167203.5. （授权日：2015-05-27）

[3] 汪新，周选围. 基于灵芝菌丝分泌酶的灵芝孢子粉优化破壁方法. 专利号：ZL 201510176449.8 (授权日：2019-07-23)

[4] 汪新，周选围.  青稞胚芽米的制备方法. 专利号：ZL 201310441514.6. (授权日：2015-06-19) 

[5] 周选围，王雪飞，李奇璋，苏恺奇，丛蔚然. 灵芝属间的重组真菌免疫调节蛋白基因、该基因编码的蛋白及其应用。专利号: ZL 2011 1 0068761.7 （授权日：2013-05-1）

[6] 周选围，王雪飞，李奇璋，苏恺奇，丛蔚然. 灵芝属内重组的真菌免疫调节蛋白基因、该基因编码的蛋白及其应用。专利号: ZL 2011 1 0068813.0 （授权日：2013-05-01）

[7] 李奇璋，周选围. 真菌免疫调节蛋白基因启动子、重组载体及宿主细胞. 专利号：ZL 2009 1 0309882.9 （授权日：2012-07-04）

[8] 周选围，龚振华，唐克轩. 北冬虫夏草甘油醛-3-磷酸脱氢酶基因启动子. 专利号：ZL 2009 1 0046694.1 （授权日：2012-06-13）

[9] 汪新, 周选围. 虫草多糖含片及其制备方法. 专利号ZL2008 1 0036761.7（授权日：2011-09-21）

[10]周选围, 林娟, 李奇璋, 尹燡周, 唐克轩.利用特异基因序列鉴别药用灵芝的检测方法.专利号: ZL2007 1 0170772.X. （授权日：2010-06-30）

 

代表性专著或译著：

[1] 主编：《生物技术概论》（高等教育出版社，2019年（第2版）。 (国家“十二五”规划教材)

[2] 主编：《天然抗癌植物资源与开发利用》（西北大学出版社，1999）。

[3] 编著：《学业评价的原理与技术》（陕西师范大学出版社，2002）。

[4] 参编：《Edible and Medicinal Mushrooms: Technology and Application》（John Wiley & Sons Ltd, 2017）。

[5] 参编：《中草药生物技术》(复旦大学出版社，2005)。

[6] 参编：《体外培养的原理和技术》（科学出版社，2001）。