余    刚 职       称：长聘教轨副教授，PI，博士生导师 所属学科：植物科学系（植物病理学） 研究方向：茄科作物与青枯菌分子互作 电子信箱：gangyu@sjtu.edu.cn

 

个人简历：

2022.6-至今 必威，课题组长，博士生导师

2016-2022 中科院分子植物科学卓越创新中心 (上海植物逆境中心)，博士后

2013-2015 美国加州大学戴维斯分校 (UC Davis)，植物病理系，联合培养博士

2010-2016 吉林大学，植物科学学院，植物学博士

2006-2010 吉林大学，植物科学学院，植物保护学士

ORCID: https://orcid.org/0000-0002-6720-7490

 

主要研究内容：

课题组围绕茄科作物(番茄，马铃薯，烟草)与青枯菌分子互作展开工作，前期发现青枯菌通过分泌三型效应因子（T3E），抑制植物抗病反应，操纵植物代谢，重编程根部发育，从而壮大病菌种群及增加侵染点，最终使植物发病。

课题组现以茄科作物与青枯菌分子互作为研究模式，从茄科作物与病原细菌两个方面开展工作，核心回答茄科作物抗病机制解析及挖掘利用抗病基因这个重要问题。主要包括：

1、细胞壁主动参与抗病反应分子机制。

2、效应子蛋白操纵植物免疫及发育分子机制。

3、新型抗病受体蛋白挖掘及应用。

 

主要承担项目：

(1)  纤维素合成相关蛋白CSI1介导的植物细胞壁免疫机制研究，国家自然科学基金面上项目，2023.1-2026.12，主持；

(2)  植物根系对病原细菌的天然免疫分子机制解析，国家自然科学基金面上项目，2022.1-2024.12，主要参与人 (2/5)；

(3)  植物性状形成的环境塑造机制(病原体侵染与植物营养代谢相互作用的机制研究)，中国科学院战略性先导科技专项(B类)，2018-2023，主要参与人 (2/4)；

(4) 番茄青枯病菌效应子蛋白Rip32生化与生物学功能解析，中国博士后基金一等资助，2016.11-2018.11，主持。

 

主要研究论文(^#为一作，^*为通讯)

(14) Gang Yu*, Lu Zhang, Hao Xue, Yujiao Chen, Xin Liu, Juan C. del Pozo, Chunzhao Zhao, Rosa Lozano-Duran, and Alberto P. Macho*. Cell wall-mediated root development is targeted by a soil-borne bacterial pathogen to promote infection. Cell Reports, 2024, in press.

(13) Gang Yu#,*, Lu Zhang#, Keke Wang , Alberto P. Macho*. Inoculation of Arabidopsis seedlings with Ralstonia solanacearum in sterile agar plates. STAR-Protocols, 2023, 4, 102474.

(12) Gang Yu#, Maria Derkacheva#,*, Jose S. Rufian#, Carla Brillada, Kathrin Kowarschik, Shushu Jiang, Paul Derbyshire, Miaomiao Ma, Thomas A. DeFalco, Rafael J. L. Morcillo, Lena Stransfeld, Yali Wei, Jian-Min Zhou, Frank L.H. Menke, Marco Trujillo, Cyril Zipfel*, and Alberto P. Macho*. The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type-III effector. The EMBO Journal, 2022, 41(23): e107257.

(11) Suhui Lv#, Yu Yang#, Gang Yu#, Li Peng, Shuai Zheng, Sunil Kumar Singh, Juan Ignacio     Vílchez, Richa Kaushal, Hailing Zi, Dian Yi, Yuhua Wang, Shaofan Luo, Xiaoxuan Wu, Ziwei Zuo, Weichang Huang, Renyi Liu, Jiamu Du, Alberto P Macho, Kai Tang, Huiming Zhang*. Dysfunction of histone demethylase IBM1 in Arabidopsis causes autoimmunity and reshapes the root microbiome. The ISME Journal, 2022, 16: 2513-2524.

(10) Lu Zhang#, Gang Yu#, Hao Xue#, Meng Li, Rosa Lozano-Duran*, and Alberto P. Macho*. Ralstonia solanacearum alters root developmental programs in auxin-dependent and independent manners. 2022, bioRxiv, doi: 10.1101/2022.06.22.497157.

(9) Liping Wang#*, Gang Yu#*, Alberto P. Macho, and Rosa Lozano-Duran. Split-luciferase complementation imaging assay to study protein-protein interactions in Nicotiana benthamiana. Bio-protocol, 2021, 11(23): e4237.

(8) Gang Yu*, Liu Xian, Haiyan Zhuang and Alberto Macho*. SGT1 is not required for plant LRR-RLK-mediated immunity. Molecular Plant Pathology, 2021, 22: 145-150.

(7) Gang Yu, Liu Xian, Hao Xue, Wenjia Yu, Jose Rufian, Yuying Sang, Rafael Morcillo, Yaru Wang, and Alberto P. Macho*. A bacterial effector protein prevents MAPK-mediated phosphorylation of SGT1 to suppress plant immunity. PLoS Pathogens, 2020, 16(9):e1008933.

(6) Liu Xian#, Gang Yu#, Yali Wei, Yansha Li, Hao Xue, Rafael J. L. Morcillo, Jose S. Rufian, and Alberto P. Macho*. A bacterial effector protein hijacks plant metabolism to support bacterial nutrition. Cell Host & Microbe, 2020, 28(4): 548-557.

(5) Gang Yu, Liu Xian, Yuying Sang, Alberto P. Macho*. Cautionary notes on the use of Agrobacterium-mediated transient gene expression upon SGT1 silencing in Nicotiana benthamiana. New Phytologist, 2019, 222: 14-17.

(4) Ling Liu, Qiaochu Wang, Ying Sun, Yanhua Zhang, Xianghui Zhang, Jinliang Liu, Gang Yu*, and Hongyu Pan*. Sssfh1, a gene encoding a putative component of the RSC chromatin remodeling complex, is involved in hyphal growth, reactive oxygen species accumulation, and pathogenicity in Sclerotinia sclerotiorum. Frontiers in Microbiology, 2018, 9: 1828. 

(3) Xinhua Sun, Gang Yu*, Jingtao Li, Jinliang Liu, Xueliang Wang, Genglin Zhu, Xianghui Zhang, and Hongyu Pan*. AcERF2, an ethylene-responsive factor of Atriplex canescens, positively modulates osmotic and disease resistance in Arabidopsis thaliana. Plant Science, 2018, 274: 32-43.

(2) Gang Yu, Jingtao Li, Xinhua Sun, Yanzhi Liu, Xueliang Wang, Hao Zhang, and Hongyu Pan*. Characterization of salinity tolerance genes expressed in salt-treated Atriplex canescens, IJMS, 2017, 18(11), 2444.

(1) Jingtao Li#, Gang Yu#, Xinhua Sun, Yanzhi Liu, Jinliang Liu, Xianghui Zhang, Chengguo Jia, Hongyu Pan*. AcPIP2, a plasma membrane intrinsic protein from halophyte Atriplex canescens, enhances plant growth rate and abiotic stress tolerance when overexpressed in Arabidopsis thaliana, Plant Cell Reports, 2015, 24(8): 1401-1415.

 

学术期刊发表的非第一作者论文

(11) Keke Wang, Wenjia Yu, Gang Yu, Lu Zhang, Liu Xian, Yali Wei, Jessica Perez-Sancho, Hao Xue, Jose S. Rufian, Haiyan Zhuang, Chian Kwon, Alberto P. Macho. A bacterial type III effector targets plant vesicle-associated membrane proteins. Molecular Plant Pathology, 2023, 24, 1154-1167.

(10) Choghag Demirjian#, Narjes Razavi#, Gang Yu, Baptiste Mayjonade, Lu Zhang, Fabien  Lonjon, Fabien Chardon, Sébastien Carrere, Jérome Gouzy, Stéphane Genin, Alberto P.  Macho, Fabrice Roux, Richard Berthomé, Fabienne Vailleau. An atypical NLR gene confers bacterial wilt susceptibility in Arabidopsis. Plant Communications, 2023, 4: 100607.  

(9) Jingtao Li, Xiaoying Ma, Chenyang Wang, Sihui Liu, Gang Yu, Mingming Gao, Hengwei   Qian, Mengjie Liu, Ben F Luisi, Dean W Gabriel, Wenxing Liang*. Acetylation of a fungal  effector that translocates host PR1 facilitates virulence. eLife, 2022, 11: e82628.

(8) Julian Dindas#, Thomas A. DeFalco#, Gang Yu, Lu Zhang, Pascale David, Marta Bjornson, Marie-Christine Thibaud, Valéria Custódio, Gabriel Castrillo, Laurent Nussaume, Alberto P. Macho, and Cyril Zipfel*. Direct inhibition of phosphate transport by plant immune signaling. Current Biology, 2022, 32 (2), 488-495.

(7) Yanru Wang#, Liu Xian#, Gang Yu, and Alberto P. Macho*. Tomato stem injection for the precise assessment of Ralstonia solanacearum fitness in planta. Bio-protocol, 2021, 11(16): e4134.

(6) Liu Xian, Gang Yu, and Alberto P. Macho*. The GABA transaminase GabT is required for full virulence of Ralstonia solanacearum in tomato. microPublication Biology, 2021, DOI: 10.17912/micropub.biology.000478.

(5) Yaru Wang, Rafael Morcillo, Achen Zhao, Gang Yu, Hao Xue, Jose S. Rufian, Yuying Sang, and Alberto P. Macho*. A bacterial effector uncovers a metabolic pathway involved in resistance to bacterial wilt disease. Molecular Plant, 2021, 14(8):1281-1296.

(4) Yuying Sang#, Wenjia Yu#, Haiyan Zhuang, Yali Wei, Lida Derevnina, Gang Yu, Jiamin Luo, Alberto P. Macho*. Intra-strain elicitation and suppression of plant immunity by Ralstonia solanacearum type-III effectors in Nicotiana benthamiana. Plant Communications, 2020: 10.1016/j.xplc.2020.100025.

(3) Huidong Fan, Gang Yu, Yanzhi Liu, Xianghui Zhang, Jinliang Liu, Yanhua Zhang, Jeffery A. Rollins, Fengjie Sun, and Hongyu Pan*. An atypical forkhead containing transcription factor SsFkh1 is involved in sclerotial formation and is essential for pathogenicity in Sclerotinia sclerotiorum, Molecular Plant Pathology, 2017, 18(7):963-975.

(2) Jingtao Li, Gang Yu, Xinhua Sun, Xianghui Zhang, Jinliang Liu and Hongyu Pan*. AcEBP1, an ErbB3-Binding Protein (EBP1) from halophyte Atriplex canescens, negatively regulates cell growth and stress responses in Arabidopsis, Plant Science, 2016, 248: 64-74.

(1) DongHyuk Lee, Gildas Bourdais, Gang Yu, Silke Robatzek, and Gitta Coaker*. RIN4 phosphorylation enhances plant plasma membrane H+-ATPase activity and inhibits flagellin-triggered immune responses. The Plant Cell, 2015, 27 (7):2042-2056.

 

授权及公开专利

(1) 潘洪玉，余刚，李敬涛，孙新华，贾成国，刘金亮，张祥辉. 四翅滨藜半胱氨酸蛋白酶基因克隆及其应用. 专利号：ZL201410497324.0

(2)  潘洪玉，余刚，李敬涛，孙新华，张祥辉，贾成国，刘金亮. 四翅滨藜锌指蛋白基因克隆及其应用. 专利号：ZL201410497473.7 

(3)  潘洪玉，余刚，张世宏，刘金亮，陈宣明，王雪亮，贾承国，李桂华. 包含脱水素功能域的基因及其抗旱抗碱基因工程应用.专利号：ZL 201110401136.X

(4)  潘洪玉，余刚，张世宏，刘金亮，陈宣明，李敬涛，贾承国，李桂华. 一种植物抗逆蛋白AcNAD及其编码基因的应用. 专利号：ZL201110401191.9

(5)  潘洪玉，余刚，张世宏，刘金亮，陈宣明，孙新华，贾承国，李桂华.一种植物水通道蛋白及其编码基因的应用. 专利号：ZL201110401450.8

(6)  潘洪玉，余刚，张世宏，刘金亮，陈宣明，贾承国，李敬涛，李桂华. 一种植物抗逆蛋白AcLRR及其编码基因的应用. 专利号：ZL201110401194.2

(7)  潘洪玉，余刚，张世宏，刘金亮，陈宣明，王雪亮，贾承国，李桂华. 包含DREB功能域的四翅滨藜基因及抗逆基因工程应用. 公开号：CN102492031A

(8)  潘洪玉，余刚，张世宏，刘金亮，陈宣明，贾承国，李敬涛，李桂华. 一种植物抗逆蛋白AcTPR及其编码基因的应用. 公开号： CN102391368A

 

奖项与荣誉

(1)  2021年上海市植物病理学会学术年会暨植物抗病免疫理论与实践国际学术研讨 大会报告一等奖

(2)  2020年全国植物生物学大会墙报一等奖

(3)  植物抗逆新基因与诱导型启动子生物学功能解析，吉林省自然科学二等奖，2020 (排名第七).

(4)  博士研究生国家奖学金 2012，2013

 

招生和招聘

欢迎对本课题组研究方向感兴趣的优秀博士生应聘博士后和专职科研岗；

欢迎有植物病理学、遗传学和生物化学背景的学生报考本实验室硕士、博士研究生及推免硕博生；

欢迎本科生到本课题组做实验实习，参与科研项目，毕业设计。