陈     焕 职       称：长聘教规副教授，博士生导师，PI 所属学科：植物科学 研究方向：植物病原菌互作-水杨酸-系统获得抗性 联系地址：我院创新楼B329B 电子信箱：huan.chen@sjtu.edu.cn

 

个人简历：

陈焕，2004年本科毕业于苏州大学生物科学系，2011年2月获得韩国庆尚大学博士学位，同年5月加入韩国庆尚大学WCU项目开展非细胞自主性转录因子介导细胞间通讯的研究；2014年任美国南卡罗来纳大学生物科学系博士后研究员，从事植物-病原菌互作研究并在水杨酸的调控机理方面取得了重要进展。2022年全职回国加入上海交通大学植物科学系，任长聘教轨副教授、博士生导师，建立了植物激素介导抗病免疫实验室。其团队长期从事水杨酸介导抗病免疫的机制研究以及深入探究病原菌-植物-环境间的互作关系，迄今以第一和共通讯作者身份在Cell Host & Microbe, Science Advances, New Phytologist, Nature Plants, Molecular Plant, Trends in Plant Science, Trends in Microbiology等国际权威期刊发表论文15篇。目前担任国际学术期刊Molecular Plant-Microbe Interactions 编委和Plant Biotechnology Journal客座编辑等。

 

工作经历：

2022.8-至今，上海交通大学，博士生导师，团队负责人

2014.5-2022.3 美国南卡罗来纳大学，植物病原菌互作，博士后研究员

2011.5-2014.2 韩国庆尚大学，WCU植物细胞间通讯, 高级研究员

教育经历：

2006.9-2011.2 韩国庆尚大学应用生命科学部，环境生命科学专业，理学博士

2004.9-2006.8 韩国庆尚大学应用生命科学部，植物分子生物学专业，理学硕士

2000.9-2004.6 苏州大学生命科学学院，生物科学（师范）专业，理学学士

 

主要研究内容：

1. 水杨酸信号转导和系统获得抗性

2. 病原菌效应蛋白

3. 环境-植物-病原菌互作

 

教书育人情况：

2019-2020年，美国南卡罗来纳大学科学拓展实验室（高中生）：柑橘黄龙病的快速分子检测

2015-2021年，美国南卡罗来纳大学荣誉本科生：Justin Wright (2021, Magellan mini-grant awardee); Connor Lewis (2020, Magellan scholarship awardee); Michael Clinton (2019-2020, Chen et al., 2019, Molecular Plant); John Korin (2018, Qi et al., 2018, Molecular Plant); Jon McGill (2017, Chen et al, 2017, Cell Host & Microbe); Aaron Mennitt (2016) ; Richard Bidwell (2015)

 

获奖情况：

2023年，上海市海外高层次人才

2013年，韩国庆尚大学杰出青年研究员奖

2010年，韩国生命科学学会暨国际学术研讨会最佳海报奖

2003、2004年，苏州大学三好学生和优秀毕业生

2003、2004年，苏州大学朱敬文奖学金

2003、2004年，苏州大学人民综合一等奖学金

 

学术服务：

Molecular Plant-Microbe Interactions（Associate Editor, 编委）

Plant Biotechnology Journal（Associate Editor, 客座编辑）

Stress Biology（客座编辑）

 

研究领域及主要学术成果：

主要从事植物与病原菌互作及激素调控植物免疫的研究。探究病原菌分泌的毒性蛋白在植物体内操控和抑制宿主免疫系统及生理活动，干扰细胞活动并最终引发病害的机理。在（1）植物病原细菌三型效应子作用免疫性机理、免疫关键调节因子调控水杨酸等防御激素信号转导机制，（2）非细胞自主性转录因子参与细胞间转运的分子进化机制，（3）以及植物响应高温胁迫的调控机制等方面开展了创新性工作并取得了一系列重要成果。

实验室将基于以上研究内容并综合运用分子遗传学、细胞生物学、生物化学等手段继续深入探索病原菌-植物-环境间的病害三角关系，解析病原菌致病机理及植物防御和抗病机制。近年来以第一和通讯作者身份在Cell Host & Microbe, Science Advances, New Phytologist, J Integr Plant Biol (封面)，Biochem Biophys Res Commun, Plant Signal Behav, Trends in Microbiology, Molecular Plant, Nature Plants,，Plant Cell & Environmen，Virulence等学术期刊发表10余篇，累计发表30余篇期刊论文。

 

代表论文：

HUAN CHEN - Google Scholar: https://scholar.google.com/citations?user=uj76wkEAAAAJ&hl=en

1. Zhu F*, Wang XW, Chen H*, Wen J* (2023). Chiral nanopesticides: the invincible opponent of plant viruses. Trends in Plant Science, Nov 21:S1360-1385(23)00369-2. (*Co-corresponding author).
2. Ikram AU, Jing Y, Chen H*, Chen J* (2023). Bacteria deploy water channels to aid infection in plants. Trends in Plant Science, 28:S1360-1385(23)00413-2. (*Co-corresponding author) 
3. Wang Y, Risteski P, Yang Y, Chen H, Droby G, Walens A, Jayaprakash D, Troester M, Herring L, Chernoff J, Tolic IM, Bower J, Vaziri C (2023). The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation. Nucleic Acids Research, gkad766
4. Islam F, Liu S, Chen H*, Chen J* (2023). Reprogramming of hormone-mediated antiviral responses in plants by viruses: A molecular tug of war on the salicylic acid-mediated immunity. Molecular Plant. (*Co-corresponding author).
5. Zhu F, Cao MY, Zhang QP, Mohan R, Schar J, Mitchell M, Chen H, Liu F, Wang D, Fu ZQ (2023). Join the green team: Inducers of plant immunity in the plant disease sustainable control toolbox. Journal of Advanced Research. S2090-1232(23)00122-4.
6. Chen H, Chen J, Zhao Y, Liu F, Fu ZQ (2022). Pseudomonas syringae pathovars. Trends in Microbiology. (IF 18.230).
7. Chen H, Li M, Qi G, Zhao M, Wang D, Liu F, Fu ZQ (2021). Two interacting transcriptional coactivators NPR1 and EDS1 cooperatively control plant immune responses. Science Advances, 7(45): eabl7173. (IF 14.957). 
8. Qi G, Chen H, Zheng H, Tang X, Chen J, Wang Y, Bai MY, Liu F, Wang D, Fu ZQ (2021). The BZR1-EDS1 module coordinates plant growth-defense coordination. Molecular Plant, 14(12)2072-2087. (IF 21.949).
9. Chen H, Chen J, Li M, Chang M, Xu K, Shang Z, Zhao Y, Palmer IA, Zhang Y, McGill J, Alfano JR, Nishimura MT, Liu F, Fu ZQ (2017). A Bacterial type III effector targets the master regulator of salicylic acid signaling NPR1 to subvert plant immunity. Cell Host & Microbe 22: 777-788.e7. (IF 31.316).

Featured by the F1000Prime Faculty (Frank White, 2018): Recommended as a new finding, good for teaching and interesting hypothesis article. Highlighted in “NPR1 in JazzSet with Pathogen Effectors” (Sun et al., 2018), Trends in Plant Science.

10. Liu L, Li Y, Xu Z, Chen H, Zhang J, Manion B, Liu F, Zou L, Fu ZQ, Chen G (2022). The Xanthomonas type III effector XopAP prevents stomatal closure by interfering with vacuolar acidification. J. Integr. Plant Biol. (IF 9.106).
11. Liu N, Chen H, Wang X, Wang D, Fu ZQ (2022). TIRggering cell death via two enzymatic reactions. Molecular Plant 15(8): 1263-1265. Spotlight. (IF 21.949).
12. Chang M, Chen H, Liu F, Fu ZQ (2022). PTI and ETI: convergent pathways with diverse elicitors. Trends Plant Science. Spotlight. (IF 22.102).
13. Chen J, Chen H, Liu F, Fu ZQ (2022). A war on the cell wall. Molecular Plant. Spotlight. (IF 13.164).
14. Khan MSS, Islam F, Chen H, Chang M, Wang D, Liu F, Fu ZQ, Chen J (2022). Transcriptional coactivators: Driving Force of Plant Immunity. Front. Plant Sci. Review (IF 6.627).
15. Chen J*, Zhang J, Kong M, Freeman A, Chen H*, Liu F* (2021). More stories to tell: NONEXPRESSOR OF PATHOGENESIS RELATED GENES1, a salicylic acid receptor. Plant Cell & Environment: 44(6):1716-1727. (*Co-corresponding author). Review (IF 7.947).
16. Meng F, Yang C, Cao J, Chen H, Pang J, Zhao Q, Wang Z, Fu ZQ, Liu J (2020). A bHLH transcription activator regulates defense signaling by nucleo-cytosolic trafficking in rice. J. Integr. Plant Biol. 62(10), 1552-1573. (IF 9.106).
17. Chen H, Liu F, Fu ZQ (2019). Deceiving the chaperone. Nature Plants 5:1110-1111. News & views. (IF 17.352).
18. Chen H, Clinton M, Qi G, Wang D, Liu F, Fu ZQ (2019). Connecting the Dots: a new and complete salicylic acid biosynthesis pathway. Molecular Plant 12(12): 1539-1541. Spotlight. (IF 21.949).
19. Palmer IA, Chen H, Chen J, Chang M, Li M, Liu F, Fu ZQ (2019). Novel salicylic acid analogs induce a potent defense response in Arabidopsis. Int J. Mol. Sci 20(13):3356. (IF 6.208).
20. Chen J, Mohan R, Zhang Y, Li M, Chen H, Palmer IA, Chang M, Qi G, Spoel SH, Mengiste T, Wang D, Liu F, Fu ZQ (2019). NPR1 promotes its own and target gene expression in plant defense by recruiting CDK8. Plant Physiol. pp.00124. (IF 8.005).
21. Chang M, Zhao J, Chen H, Li G, Chen J, Li M, Palmer IA, Song J, Alfano JR, Liu F, Fu ZQ (2019). PBS3 protects EDS1 from proteasome-mediated degradation in plant immunity. Molecular Plant 12(5):678-688. (IF 21.949).
22. Chen H, Palmer I, Chen J, Thompson S, Liu F, and Fu Z.Q (2018). Specific and accurate detection of the citrus greening pathogen Candidatus liberibacter spp. using conventional PCR on citrus leaf tissue samples. JOVE. (IF 1.424).
23. Li M, Chen H, Chen J, Chang M, Palmer IA, Gassmann W, Liu F, Fu ZQ (2018). TCP transcription factors interact with NPR1 and contribute redundantly to systemic acquired resistance. Front Plant Sci. 14;9:1153. (IF 6.627).
24. Qi G, Chen J, Chang M, Chen H, Hall K, Korin J, Liu F, Wang D, Fu ZQ (2018). Pandemonium breaks out: Disruption of salicylic acid-mediated defense by plant pathogens. Molecular Plant 11(12):1427-1439. Review (IF 21.949).
25. Wu L*, Chen H*, Curtis C, Fu ZQ (2014). Go in for the kill. How plants deploy effector-triggered immunity to combat pathogens. Virulence 5:7, 1012. (*Co-first author). (IF 5.428).
26. Chen H, Ahmad M, Rim Y, Lucas WJ, Kim JY (2013). Evolutionary and molecular analysis of Dof transcription factors identified a conserved motif for intercellular protein trafficking. New Phytologist 198(4): 1250-60. (IF 10.323). 
27. Chen H, Jackson D, Kim JY (2014). Identification of evolutionarily conserved amino acid residues in homeodomain of KNOX proteins for intercellular trafficking. Plant Signaling & Behavior 9:e28355. (IF 2.734). 
28. Kumar D, Chen H, Rim Y, Kim JY (2015). GAL4 transactivation-based assay for the detection of selective intercellular protein movement. Plasmodesmata. Methods Mol. Biol. 1217:231-43. Method (IF 1.187).
29. Han X, Kumar D, Chen H, Wu S, Kim JY (2014). Transcription factor-mediated cell-to-cell signaling and its regulation. J. Exp. Bot. 65:1737-49. Review (IF 7.298). Q1-1
30. Ahmad M, Rim Y, Chen H, Kim JY (2013). Functional characterization of Arabidopsis Dof transcription factor AtDof4.1. Russ. J. Plant Physiol. 60: 116-123. (IF 1.419). Q3-4
31. Je J, Chen H, Song C, Lim CO (2014). Arabidopsis DREB2C modulates ABA biosynthesis during germination. Biochem. Biophys. Res. Commun 452:91-98. (IF 3.322). 
32. Chen H, Je J, Song C, Hwang JE, Lim CO (2012). A proximal promoter region confers tissue-specific expression of Arabidopsis DREB2C under heat stress. J. Integr. Plant Biol. 54: 640-51 (Cover Story). (IF 7.061).
33. Chen H, Hwang JE, Lim CJ, Kim DY, Lee SY, Lim CO (2010). Arabidopsis DREB2C functions as a transcriptional activator of HsfA3 during the heat stress response. Biochem. Biophys. Res. Commun 401: 238-244. (IF 3.322).
34. Hwang JE, Lim CJ, Chen H, Je J, Song C, Lim CO (2011). Overexpression of Arabidopsis dehydration responsive element binding protein 2C confers tolerance to oxidative stress. Mol. Cells 33: 1-10. (IF 4.250).
35. Hwang JE, Hong JK, Lim CJ, Chen H, Je J, Yang KA, Kim DY, Choi Y., Lee SY, Lim CO (2010). Distinct expression patterns of two Arabidopsis phytocystain genes, AtCYS1 and AtCYS2, during development and abiotic stress. Plant Cell Rep. 29: 905-915. (IF 4.964).
36. Lim CJ, Hwang JE, Chen H, Hong JK, Yang KA, Choi MS, Lee KO, Chung WS, Lee SY, Lim CO (2007). Over-expression of the Arabidopsis DRE/CRT-binding transcription factor DREB2C enhances thermotolerance. Biochem. Biophys. Res. Commun. 362: 431-436. (IF 3.322).
37. Gu QY, Shen SD, Xiang WY, Chen H (2005). Studies on the solid culture of somatic cells from Porphyra haitanensis. J. Suzhou Univ. (Nat. Sci.) 21(3).