王传徳 职      称：长聘教轨副教授（课题组长，博士生导师） 所属学科：植物科学系/园艺学 研究方向：植物细胞器基因表达调控 电子信箱：chuandewang@sjtu.edu.cn 联系地址：必威A楼3-406

 

个人简历：

2023.08-至今 必威，课题组长，博士生导师

2019-2023 法国国家农业科学院IJPB研究所，博士后

2014-2018 法国巴黎萨克雷大学，博士

2011-2014 中国科学院大学武汉植物园，硕士

 

入选国家级青年人才计划，上海市海外高层次人才引进计划

 

主要研究领域：

线粒体和叶绿体是植物细胞中两个重要的细胞器，与能量代谢密切相关。在原始内共生体转向细胞器的进化过程中，叶绿体和线粒体的大多数基因发生了丢失或转移到宿主的核基因组上，也伴随着大量参与控制细胞器基因表达的细胞核编码因子的进化。理解细胞核与细胞器之间的互作关系不仅对研究核质基因协同进化具有重要科学意义，也将为植物杂交育种和杂种优势利用提供理论依据。

本实验室旨在研究核基因与线粒体和叶绿体基因之间的功能和遗传基础，重点关注线粒体和叶绿体基因表达分子机制及空间网络，以深入探讨核质互作在植物发育、繁殖以及环境适应方面的关键作用。同时建立细胞器遗传转化和基因编辑平台，促进杂种优势的利用和植物遗传改良。

主要包括：

1）细胞器转录后表达调控

2）细胞质雄性不育与育性恢复

3）细胞器基因编辑

 

研究成果：

1) 揭示了十字花科作物细胞质雄性不育与育性恢复的分子机制 (PNAS, 2021; JXB, 2013; Mol. breeding, 2015; Mol. breeding, 2017)；

2) 鉴定了核糖体蛋白等RNA结合蛋白参与细胞器内含子剪接事件 (Nucleic Acids Research 2024; PNAS, 2020; JXB, 2018);

3) 较系统地阐明了线粒体 RNA 的 3’ 端加工成熟的多样性分子机制及其与内含子反式剪接的内在联系(Nucleic Acids Research, 2017; Nucleic Acids Research, 2023; Plant Physiology, 2022).

 

 

近期代表性论文：

1. Chuande Wang, Martine Quadrado and Hakim Mireau (2024). Temperature-sensitive splicing defects in Arabidopsis mitochondria caused by mutations in the ROOT PRIMORDIUM DEFECTIVE 1 gene. Nucleic acids research. 1-13, gkae072.

2. Huy Cuong Tran, Vivian Schmitt, Sbatie Lama, Chuande Wang, Alexandra Launay-Avon, Katja Bernfur, Kristin Sultan, Kasim Khan, Véronique Brunaud, Arnaud Liehrmann, Benoît Castandet, Fredrik Levander, Allan G Rasmusson, Hakim Mireau, Etienne Delannoy, Olivier Van Aken (2023). An mTRAN-mRNA interaction mediates mitochondrial translation initiation in plants. Science. 381(6661), eadg0995.

3. Chuande Wang, Martine Quadrado, Hakim Mireau, Interplay of endonucleolytic and exonucleolytic processing in the 3′-end formation of a mitochondrial nad2 RNA precursor in Arabidopsis. Nucleic Acids Research, 2023;51(14).

4. Chuande Wang, Lisa Blondel, Martine Quadrado, Céline Dargel-Graffin, Hakim Mireau. Pentatricopeptide repeat protein MITOCHONDRIAL STABILITY FACTOR 3 ensures mitochondrial RNA stability and embryogenesis. Plant Physiology, 2022, 190(1).

5. Chuande Wang, Lina Lezhneva, Nadège Arnal, Martine Quadrado, Hakim Mireau. The radish Ogura fertility restorer impedes translation elongation along its cognate CMS-causing mRNA. Proceedings of the National Academy of Sciences, 2021, 118(35).

6. Chuande Wang, Rachel Fourdin, Martine Quadrado, Céline Dargel-Graffin, Dimitri Tolleter, David Macherel, Hakim Mireau. Rerouting of ribosomal proteins into splicing in plant organelles. Proceedings of the National Academy of Sciences, 2020, 117(47). (Recommended by F1000Prime/Faculty Opinions, DOI: 10.3410/f.739015753.793580790).

7. Chuande Wang, Fabien Aube, Noelya Planchard, Martine Quadrado, Celine Dargel-Graffin, Fabien Nogue and Hakim Mireau. The pentatricopeptide repeat protein MTSF2 stabilizes a nad1 precursor transcript and defines the 3’ end of its 5-half intron. Nucleic acids research, 2017, 45:6119-6134.

8. Chuande Wang, Fabien Aubé, Martine Quadrado, Céline Dargel-Graffin, Hakim Mireau. Three new pentatricopeptide repeat proteins facilitate the splicing of mitochondrial transcripts and complex I biogenesis in Arabidopsis. Journal of Experimental Botany, 2018, 69(21).

9. ZhiWei Wang¹, Chuande Wang¹, QingZe Cai, ShiYong Mei, Lei Gao, Yuan Zhou, Ting Wang. Identification of promoter exchange at a male fertility restorer locus for cytoplasmic male sterility in radish (Raphanus sativus L.). Molecular Breeding, 2017, 37:82. (Co-first author).

10. ZhiWei Wang¹, Chuande Wang¹, ShiYong Mei, Lei Gao, Yuan Zhou, Ting Wang. An insertion–deletion at a pentatricopeptide repeat locus linked to fertility transition to cytoplasmic male sterility in radish (Raphanus sativus L.). Molecular Breeding, 2015, 35:1-5. (Co-first author).

11. ZhiWei Wang¹, Chuande Wang¹, Lei Gao¹, ShiYong Mei, Yuan Zhou, ChangPing Xiang, and Ting Wang. Heterozygous alleles restore male fertility to cytoplasmic male-sterile radish (Raphanus sativus L.): a case of overdominance. Journal of Experimental Botany, 2013, 64:2041-2048. (Co-first author).

 

本实验室将秉承“不拘一格降人才”的理念，热切欢迎有兴趣、有热情、有梦想的青年才俊，期待与你们一同，创造充满快乐和无限可能的科研之旅。

无论你是本科生、硕士生、博士研究生，还是博士后、助理研究员等科研人员，只要你对生命科学充满兴趣，都热烈欢迎你的加盟！在这里，我们为每一位学生和研究人员提供一个广阔的舞台，让你展示自己的才华，共同探索科学的奥秘。