时    间：2023年11月15日 (星期三) 12:40-14:00

地    点：我院创新楼（B楼）104会议室

主办单位：我院学科与科技办、我院青年教师联谊会

报告题目：永无止境的传说：从病原菌效应蛋白到水杨酸受体介导的免疫调控

报告摘要：

植物和病原菌在协同进化过程中，长期处于复杂的“军备竞赛”。植物利用不同免疫受体和抗病蛋白识别并激发一系列不同强度的免疫防御反应，病原菌分泌多种毒性蛋白操纵或攻击宿主靶标以利于其侵染和增殖。通过研究细菌三型效应蛋白对宿主细胞水杨酸受体介导的免疫调节作用，揭示病原菌致病新机制以及植物免疫共激活因子复合体调控免疫的新通路，为培育广谱持久高抗作物、开发绿色农药以及预防人类疾病提供新型靶标和种质资源。

报告人简介：

陈焕博士2011年在韩国国立庆尚大学校应用生命科学部，获得环境生命科学博士学位。随后在庆尚大学校World Class University项目和美国南卡罗来纳大学生物科学系从事博士后独立研究工作。2022入职必威，独立PI，博士生导师。主要研究方向为水杨酸信号转导及其相关的系统获得抗性、效应蛋白调节宿主生理生化过程，以第一和通讯作者（含共同）在Cell Host & Microbe, Science Advances, New Phytologist, Trends in Microbiology，Nature Plants, Molecular Plant，JIPB(封面)等国际刊物发表论文10余篇，共发表论文近40篇。

【所在学科研究组研究方向】：

1）水杨酸信号通路和系统获得抗性；

2）效应蛋白调节宿主生理生化过程；

3）环境-植物-病原菌互作关系。

【代表性著作】：

1. Chen H, Chen J, Zhao Y, Liu F, Fu ZQ (2022). Pseudomonas syringae pathovars. Trends in Microbiology. 
2. Chen H, Li M, Qi G, Zhao M, Wang D, Liu F, Fu ZQ (2021). Two interacting transcriptional coactivators NPR1 and EDS1 cooperatively control plant immune responses. Science Advances, 7(45): eabl7173.
3. Chen H, Clinton M, Qi G, Wang D, Liu F, Fu ZQ (2019). Connecting the Dots: a new and complete salicylic acid biosynthesis pathway. Molecular Plant 12(12): 1539-1541.
4. Chen H, Chen J, Li M, Chang M, Xu K, Shang Z, Zhao Y, Palmer IA, Zhang Y, McGill J, Alfano JR, Nishimura MT, Liu F, Fu ZQ (2017). A Bacterial type III effector targets the master regulator of salicylic acid signaling NPR1 to subvert plant immunity. Cell Host & Microbe 22: 777-788.e7. Featured by the F1000Prime Faculty (Frank White, 2018) and Highlighted in “NPR1 in JazzSet with Pathogen Effectors” (Sun et al., 2018), Trends Plant Sci.
5. Chen H, Ahmad M, Rim Y, Lucas WJ, Kim JY (2013). Evolutionary and molecular analysis of Dof transcription factors identified a conserved motif for intercellular protein trafficking. New Phytologist 198(4): 1250-60.

ACADEMIC SALON (XLV)

SPEAKER: Huan Chen

Associate Professor, Department of Plant Science, SAB

TIME ：12:40-14:00 November 15th, 2023 (Wed)

VENUE：Room 104, Building B, SAB

ORGANIZER：Office of Discipline and Science & Technology, SAB;

Young Teachers Association, SAB

TITLE： 

A Never-Ending Saga: From Bacterial Pathogen Effectors to the Master Immune Coactivators to Boost Plant Immunity

ABSTRACT：

To recognize non-self and defense against pathogen infection, plants and animals rely on a consecutive and multi-layered innate immune system governed by integration of multiple cell-face and intracellular immune receptors. During host-pathogen coevolution, phytopathogenic bacteria suppress diverse plant immune systems and promote pathogenesis by injecting proteins called type III effectors into plant cells using a type III protein secretion. Based on the identification and functional study of a bacterial type III effector AvrPtoB that targets the salicylic acid (SA) receptor, we have found a novel strategy by the pathogen to promote pathogenesis and revealed the underlying mechanisms utilized by SA-activated transcriptional coactivators to boost plant immunity. This emerging discovery will help in identifying germplasm resources involved in the cultivation of broad-spectrum, durable and highly resistance crops, the development of environmentally friendly pesticides, and the prevention of human disease.