WU GUOZHANG   Associate Professor/Principal Investigator Department of Plant Science Email: gzwu@sjtu.edu.cn Address: Room 523, Building B, School of Agriculture and Biology

 

 

>> Education and Employment

2019.9-present, Associate professor, group leader of Max Planck Partner Group “Organelle and Stress Biology”, Shanghai Jiao Tong University

2013.9-2019.8, Scientist, Max Planck Institute of Molecular Plant Physiology

2011.9-2013.8, Humboldt Scholar, Max Planck Institute of Molecular Plant Physiology

2010.11-2011.8, Postdoc, Max Planck Institute of Molecular Plant Physiology

2004.9-2010.10, PhD, Shanghai Institute of Plant Physiology and Ecology, CAS

 

>>Research Interests

Plastids (chloroplasts) are essential organelles that harbor photosynthesis and the biosynthesis of various primary and secondary metabolites, and act as environmental sensors which participate in multiple stress response. We use state-of-the-art techniques in the lab to understand:

1. Bidirectional communication between plastids and the nucleus (anterograde and retrograde signaling).   

2. Plastid protein import and the cellular response to protein import stress, regulation of plastid protein homeostasis.

3. The role of plastids in abiotic stress, especially temperature stress.

 

>>Representative Publications (#, co-first author; *, co-correspondence author)

1. Gao, L.-L., Hong, Z.-H., Wang, Y., Wu, G.-Z.* (2022) Chloroplast proteostasis: A story of birth, life and death. Plant Commun 3: 100424.

2. Wu, G.-Z.* and Bock R.* (2021) GUN control in retrograde signaling: How GENOMES UNCOUPLED proteins adjust nuclear gene expression to plastid biogenesis. Plant Cell 33: 457-474. (Highly cited)

3. Wu, G.-Z., Meyer, E.H., Richter, A., Schuster, M., Ling, Q., Schöttler, M.A., Walther, D., Zoschke, R., Grimm, B., Jarvis, P. and Bock, R. (2019) Control of retrograde signalling by protein import and cytosolic folding stress. Nat Plants 5, 525-538. (Highly cited)

4. Wu, G.-Z., Meyer, E.H., Wu, S. and Bock, R. (2019) Extensive post-transcriptional regulation of nuclear gene expression by plastid retrograde signals. Plant Physiol 180, 2034-2048.

5. Wu, G.-Z., Chalvin, C., Hoelscher, M., Meyer, E.H., Wu, X.N. and Bock, R. (2018) Control of retrograde signaling by rapid turnover of GENOMES UNCOUPLED1. Plant Physiol 176, 2472-2495. (Highly cited)

6. Hoelscher, M., Tiller, N., Teh, A., Wu, G.-Z., Ma, J.KC. and Bock, R. (2018) High-level expression of the HIV entry inhibitor griffithsin from the plastid genome and retention of biological activity in dried tobacco leaves. Plant Mol Biol 97, 357-370.

7. Wu, G.-Z., and Xue, H.W. (2010) Arabidopsis β-ketoacyl-[acyl carrier protein] synthase 1 is crucial for fatty acid synthesis and plays a role in chloroplast division and embryo development. Plant Cell 22, 3726-3744.

8. Niu, Y.#, Wu, G.-Z.#, Ye, R., Lin, W.H., Shi, Q.M., Xue, L.J., Xu, X.D., Li, Y., Du, Y.G. and Xue, H.W. (2009) Global analysis of gene expression profiles in Brassica napus developing seeds reveals a conserved lipid metabolism regulation with Arabidopsis thaliana. Mol Plant 2, 1107-1122.

9. Wu, G.-Z., Shi, Q.M., Niu, Y., Xing, M.Q., and Xue, H.W. (2008). Shanghai RAPESEED Database: a resource for functional genomics studies of seed development and fatty acid metabolism of Brassica. Nucleic Acids Res 36, D1044-D1047.